PEI-g-PEG-SH, MW n 25K, m 2K is a thiol-functionalized graft copolymer composed of polyethyleneimine (PEI) and polyethylene glycol (PEG). It combines an amine-rich PEI backbone with PEG grafts and thiol functionality specifically for conjugation, surface modification, and biomaterial research.
Key Features and Benefits
- Graft Copolymer Structure: Features a PEI-g-PEG architecture with hydrophilic PEG chains grafted onto a cationic PEI framework.
- PEI MW 25K: Provides a high molecular weight, amine-rich PEI backbone with abundant protonatable amine groups.
- PEG MW 2K: Provides compact hydrophilic polyethylene glycol grafts that specifically help tune the polymer’s physicochemical properties.
- Thiol Functionality: Provides reactive sulfhydryl groups specifically for selective conjugation with compatible thiol-reactive molecules and surfaces.
- Thiol-Reactive Chemistry: Supports coupling with compatible maleimide, OPSS, and other thiol-reactive functional groups.
- Cationic Character: PEI provides positive charge under suitable pH conditions for electrostatic interactions with negatively charged materials.
- Amine-Rich Structure: PEI amine groups provide additional sites specifically for chemical functionalization and biomolecular interactions.
- Multifunctional Platform: Combines PEI amine functionality, PEG hydrophilicity, and thiol reactivity in one graft copolymer.
Applications
- Thiol Conjugation: Thiol groups support selective coupling with compatible maleimide, OPSS, and other thiol-reactive molecules.
- Bioconjugation: Supports attachment of compatible biomolecules, ligands, dyes, polymers, and other functional compounds.
- Polymer Functionalization: Provides thiol and amine functionality for preparing multifunctional polymer conjugates.
- Nanoparticle Functionalization: Supports thiol-mediated modification of compatible nanoparticles and nanoscale materials.
- Surface Modification: Enables functionalization of compatible surfaces specifically through thiol-reactive chemistry.
- Gold Surface Functionalization: Thiol groups support strong interactions with compatible gold surfaces and nanoparticles.
- Biomolecular Complexation: Cationic PEI supports electrostatic interactions with compatible negatively charged biomolecules and polymers.
- Biomaterial Research: Supports development of functional polymers, conjugates, nanoparticles, coatings, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Minimize prolonged exposure to air to reduce oxidation of thiol groups.
PEI-g-PEG-SH, MW n 25K, m 2K combines an amine-rich PEI framework, compact PEG grafts, and reactive thiol functionality and specifically supports thiol conjugation, polymer functionalization, nanoparticle modification, and surface functionalization.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.