PEI-g-PEG-N3, MW n 10K, m 5K is an azide-functionalized graft copolymer composed of polyethyleneimine (PEI) and polyethylene glycol (PEG). It combines an amine-rich PEI framework with hydrophilic PEG grafts and azide functionality for click chemistry, bioconjugation, and biomaterial research.
Key Features and Benefits
- Graft Copolymer Structure: Features a PEI-g-PEG architecture with hydrophilic PEG chains grafted onto a cationic PEI framework.
- PEI MW 10K: Provides an amine-rich PEI framework with multiple protonatable amine groups specifically for electrostatic interactions and functionalization.
- PEG MW 5K: Provides hydrophilic polyethylene glycol grafts that specifically contribute substantial hydrophilic character to the polymer.
- Azide Functionality: Provides reactive azide groups specifically for selective click chemistry with compatible alkyne-functionalized molecules.
- CuAAC Click Chemistry: Supports copper-catalyzed azide-alkyne cycloaddition with compatible terminal alkyne groups.
- SPAAC Click Chemistry: Supports copper-free click reactions with strained cyclooctynes such as DBCO and BCN.
- Cationic Character: PEI specifically provides positive charge under suitable pH conditions for electrostatic interactions with negatively charged materials.
- Multifunctional Platform: Combines PEI amine functionality, PEG hydrophilicity, and azide reactivity in one graft copolymer.
Applications
- Click Chemistry: Azide functionality supports CuAAC and SPAAC reactions with compatible alkyne-containing molecules.
- Bioconjugation: Enables attachment of compatible peptides, proteins, ligands, dyes, polymers, and other functional molecules.
- Polymer Functionalization: Provides azide and amine functionality for preparing multifunctional polymer conjugates.
- Nanoparticle Functionalization: Supports click-mediated modification of compatible nanoparticles and nanoscale materials.
- Surface Modification: Enables development of functional polymer coatings and modified surfaces through compatible click chemistry.
- Ligand Conjugation: Supports attachment of compatible alkyne- or cyclooctyne-functionalized ligands for research applications.
- Biomolecular Complexation: Cationic PEI specifically supports electrostatic interactions with compatible negatively charged biomolecules and polymers.
- Biomaterial Research: Supports development of functional polymers, conjugates, nanoparticles, coatings, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
PEI-g-PEG-N3, MW n 10K, m 5K combines an amine-rich PEI framework, hydrophilic PEG grafts, and reactive azide functionality and specifically supports CuAAC and SPAAC click chemistry, bioconjugation, polymer functionalization, and nanoparticle modification.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.