PEI-g-PEG-Biotin, MW n 2K, m 2K is a biotin-functionalized graft copolymer composed of polyethyleneimine (PEI) and polyethylene glycol (PEG). It combines a compact, amine-rich PEI framework with hydrophilic PEG grafts and biotin functionality for affinity binding, bioconjugation, and biomaterial research.
Key Features and Benefits
- Graft Copolymer Structure: Features a PEI-g-PEG architecture with hydrophilic PEG chains grafted onto a cationic PEI framework.
- PEI MW 2K: Provides a low molecular weight, amine-rich PEI framework with multiple protonatable amine groups.
- PEG MW 2K: Provides compact hydrophilic polyethylene glycol grafts that help tune the polymer’s physicochemical properties.
- Biotin Functionality: Provides high-affinity noncovalent recognition by avidin and streptavidin proteins.
- Avidin-Streptavidin Recognition: Supports affinity-based assembly and conjugation using compatible avidin or streptavidin systems.
- Cationic Character: PEI specifically provides positive charge under suitable pH conditions for electrostatic interactions with negatively charged materials.
- Amine-Rich Structure: PEI amine groups specifically provide additional sites for chemical functionalization and biomolecular interactions.
- Multifunctional Platform: Combines PEI amine functionality, PEG hydrophilicity, and biotin recognition in one graft copolymer.
Applications
- Biotin-Avidin Binding: Supports high-affinity interactions with compatible avidin and streptavidin proteins.
- Bioconjugation: Enables affinity-based attachment and assembly of compatible biotin-binding biomolecules and functional components.
- Polymer Functionalization: Provides biotin and amine functionality specifically for preparing multifunctional polymer systems.
- Nanoparticle Functionalization: Supports biotin-mediated modification and assembly of compatible nanoparticle systems.
- Surface Modification: Enables development of biotin-functionalized polymer coatings and modified surfaces.
- Affinity-Based Research: Supports avidin-biotin and streptavidin-biotin recognition studies and affinity-based assemblies.
- Biomolecular Complexation: Cationic PEI specifically supports electrostatic interactions with compatible negatively charged biomolecules and polymers.
- Biomaterial Research: Supports development of functional polymers, conjugates, nanoparticles, coatings, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
PEI-g-PEG-Biotin, MW n 2K, m 2K combines a compact, amine-rich PEI framework, compact PEG grafts, and biotin functionality and specifically supports avidin-streptavidin recognition, bioconjugation, polymer functionalization, and nanoparticle modification.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.