PDLLA-PEG-Mal (PDLLA-PEG-Maleimide), MW x 20K, n 2K is a maleimide-functionalized amphiphilic block copolymer. It combines 20K hydrophobic PDLLA with 2K hydrophilic PEG specifically for thiol conjugation, polymer functionalization, and drug-delivery research.
Key Features and Benefits
- Amphiphilic Block Copolymer: Combines hydrophobic PDLLA with hydrophilic PEG for polymer assembly, formulation, and biomaterial development.
- PDLLA MW 20K: Provides a biodegradable hydrophobic block specifically for core formation, polymer assembly, and incorporation of hydrophobic compounds.
- PEG MW 2K: Provides a compact hydrophilic segment specifically for aqueous compatibility, steric stabilization, and surface presentation.
- Terminal Maleimide Group: Provides a reactive maleimide group for selective conjugation with compatible thiol-containing molecules.
- Thiol-Reactive Chemistry: Maleimide readily reacts with sulfhydryl groups to form stable thioether linkages under suitable conditions.
- Bioconjugation Platform: Supports attachment of thiol-containing peptides, proteins, ligands, and other functional molecules.
- PDLLA-Rich Architecture: The 10:1 PDLLA-to-PEG molecular weight ratio strongly favors hydrophobic character while retaining a functional PEG segment.
- Biodegradable PDLLA Block: Hydrolyzable ester linkages specifically support gradual degradation of the PDLLA segment under appropriate conditions.
Applications
- Thiol Conjugation: Supports selective coupling with compatible sulfhydryl-containing molecules.
- Bioconjugation: Enables attachment of thiol-containing peptides, proteins, ligands, and other biomolecules.
- Polymer Self-Assembly: Supports formation of PDLLA-rich amphiphilic polymer assemblies.
- Nanoparticle Functionalization: Enables thiol-reactive surface modification of compatible PEG-containing polymeric nanoparticles.
- Ligand Functionalization: Supports attachment of thiol-containing targeting ligands and other functional components.
- Drug Delivery: Supports development of functional amphiphilic polymers for drug-delivery and formulation research.
- Surface Modification: Terminal maleimide provides a reactive handle for modifying compatible polymer assemblies and surfaces.
- Biomaterial Research: Supports development of functional polymer conjugates, nanoparticles, assemblies, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
PDLLA-PEG-Mal (PDLLA-PEG-Maleimide), MW x 20K, n 2K combines biodegradable PDLLA, hydrophilic PEG, and terminal maleimide functionality, while its thiol-reactive terminus supports bioconjugation, polymer assembly, nanoparticle functionalization, and drug-delivery research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.