PDLLA-PEG-Folate (PDLLA-PEG-FA), MW x 10K, n 5K is a folate-functionalized amphiphilic block copolymer. It combines 10K hydrophobic PDLLA with 5K hydrophilic PEG and terminal folate specifically for ligand-functionalized polymer research.
Key Features and Benefits
- Amphiphilic Block Copolymer: Combines hydrophobic PDLLA with hydrophilic PEG for polymer assembly, formulation, and biomaterial development.
- PDLLA MW 10K: Provides a biodegradable hydrophobic block for polymer assembly and incorporation of hydrophobic compounds.
- PEG MW 5K: Provides a substantial hydrophilic segment specifically for aqueous compatibility, steric stabilization, and surface presentation.
- Terminal Folate Group: Provides a folate ligand specifically for folate-receptor recognition and receptor-binding research.
- Folate-Receptor Recognition: Supports studies involving interactions between folate-functionalized materials and folate-binding systems.
- Ligand Presentation: The PEG segment helps present terminal folate at the surface of compatible polymer assemblies.
- PDLLA-Rich Architecture: The 2:1 PDLLA-to-PEG molecular weight ratio provides hydrophobic character with a substantial hydrophilic PEG segment.
- Biodegradable PDLLA Block: Hydrolyzable ester linkages specifically support gradual degradation of the PDLLA segment under appropriate conditions.
Applications
- Polymer Self-Assembly: Supports development of functional amphiphilic polymer assemblies.
- Nanoparticle Formulation: Supports development of folate-functionalized polymeric nanoparticles and related nanomaterials.
- Folate-Receptor Research: Provides terminal folate for studies involving folate-receptor recognition and binding.
- Ligand-Targeted Delivery: Supports research on folate-functionalized polymer systems for ligand-targeted delivery strategies.
- Surface Functionalization: Enables presentation of folate on compatible PEG-containing polymer assemblies and nanoparticle surfaces.
- Drug Delivery: Supports development of functional amphiphilic polymers for drug-delivery and formulation research.
- Biomaterial Research: Supports development of ligand-functionalized polymer assemblies, nanoparticles, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture, excessive heat, and prolonged light exposure. Allow the material to reach room temperature before opening to minimize condensation.
PDLLA-PEG-Folate (PDLLA-PEG-FA), MW x 10K, n 5K combines biodegradable PDLLA, hydrophilic PEG, and terminal folate functionality, while its 2:1 architecture supports folate-receptor research, polymer assembly, nanoparticle functionalization, and ligand-targeted delivery studies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.