PDLLA-PEG-COOH, MW x 5K, n 1K combines a 5K poly(DL-lactide) (PDLLA) segment, 1K PEG segment, and terminal carboxylic acid functionality. This biodegradable amphiphilic block copolymer specifically supports bioconjugation, nanoparticle development, drug delivery research, and functional biomaterial design.
Key Features and Benefits
- Block Copolymer Structure: Combines hydrophobic PDLLA with hydrophilic PEG for amphiphilic polymer design and formulation research.
- PDLLA MW 5K: The 5K PDLLA segment specifically provides a biodegradable hydrophobic component for polymer assembly and material development.
- PEG MW 1K: The 1K PEG segment specifically provides a compact hydrophilic spacer for polymer functionalization and formulation studies.
- Carboxylic Acid Functionality: The terminal COOH group provides a reactive site for conjugation and further polymer modification.
- EDC/NHS Activation: The carboxyl group specifically supports carbodiimide-mediated activation for coupling with primary amines.
- Stable Amide Formation: Activated carboxyl groups can react with amine-containing molecules to form covalent amide linkages.
- Amphiphilic Character: PDLLA and PEG specifically provide distinct hydrophobic and hydrophilic regions that support self-assembly in suitable environments.
- Biodegradable Polymer Platform: PDLLA specifically provides a biodegradable polyester component for delivery systems and functional biomaterial research.
Applications
- Bioconjugation: Terminal carboxyl functionality supports attachment of compatible amine-containing molecules.
- Ligand Conjugation: Enables coupling of suitable peptides, proteins, targeting ligands, and other amine-containing components.
- Nanoparticle Research: Supports development and surface functionalization of biodegradable polymeric nanoparticles.
- Polymeric Micelles: Amphiphilic PDLLA and PEG blocks specifically support research into self-assembled polymer structures.
- Drug Delivery Research: Useful for developing functionalized biodegradable polymer-based delivery systems.
- Surface Modification: Terminal COOH functionality supports further modification of appropriately designed polymer surfaces and assemblies.
- Polymer Functionalization: Provides a reactive carboxyl group for preparing customized PDLLA-PEG conjugates.
- Biomaterial Research: Supports development of biodegradable, PEG-containing functional polymer systems.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
PDLLA-PEG-COOH, MW x 5K, n 1K combines biodegradable PDLLA, hydrophilic PEG, and terminal carboxylic acid functionality, while its amphiphilic and reactive structure supports bioconjugation, nanoparticles, drug delivery, and functional biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.