PC SPDP-NHS Carbonate Ester (CAS: 2279944-61-3): Overview and Applications
The PC SPDP-NHS carbonate ester is a specialized photo-cleavable chemical compound used in biochemical and pharmaceutical research. Here’s a brief overview:
Overview
- Photo-Cleavable (PC): The linker breaks down upon exposure to light, enabling precise control over the release of attached molecules.
- SPDP: Succinimidyl 3-(2-pyridyldithio)propionate, facilitates stable disulfide bond formation with thiol-containing molecules.
- NHS: N-Hydroxysuccinimide group forms stable amide bonds with primary amines, allowing conjugation to biomolecules.
- Carbonate Ester: Contains carbonate and ester functional groups that react with primary amines to form stable covalent bonds.
Key Features
- CAS Number: 2279944-61-3
- Reactivity: The carbonate ester group forms stable covalent bonds with primary amines, enabling the creation of complex and stable biomolecular structures.
- Light-Induced Cleavage: Facilitates controlled release through light activation.
Applications
- Drug Delivery: Enhances targeted and stable delivery of drugs, improving therapeutic outcomes.
- Bioconjugation: Useful for cross-linking and attaching molecules to proteins and peptides, with light-controlled release options.
- Protein Labeling: Enables temporary tagging or labeling of proteins, which can be controlled or removed by light.
Advantages
- Precision: Provides exact control over molecular release and conjugation through both light and chemical reactions.
- Versatility: The combination of carbonate ester and NHS functionalities makes it highly versatile for creating stable biomolecular structures.
Considerations
- Light Conditions: Requires precise light exposure for effective cleavage.
- Potential Phototoxicity: Excessive light may affect nearby molecules or tissues.
The PC SPDP-NHS carbonate ester is an essential tool in the pharmaceutical industry for developing stable and targeted drug delivery systems, as well as for advanced biochemical research.
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