p-NH₂-Bn-DOTA, CAS Number 181065-46-3, is a versatile chelating agent widely used in bioconjugation, radiolabeling, and molecular imaging applications. Here’s a concise overview:
Overview
- Full Name: p-Aminobenzyl-DOTA.
- CAS Number: 181065-46-3.
- Chemical Formula: C18H28N4O8.
- Molecular Weight: 428.44 g/mol.
Key Applications
- Bioconjugation: The amino group (NH₂) allows easy attachment to biomolecules, such as proteins, peptides, or antibodies.
- Radiolabeling: DOTA acts as a strong chelator, binding metal ions like Gallium-68 (Ga-68) for PET imaging or Lutetium-177 (Lu-177) for targeted radiotherapy.
- Imaging: Frequently used in developing imaging agents for PET, SPECT, and MRI, supporting diagnostics in biomedical research.
Properties
- Amino Group (NH₂): Provides a reactive site for bonding to carboxyl or NHS-activated molecules, ideal for bioconjugation.
- Chelating Strength: DOTA forms stable complexes with metal ions, ensuring reliability in radiolabeled compounds.
Handling and Storage
- Storage: Store in a cool, dry place to maintain stability.
- Handling: Use standard protective measures to prevent unwanted reactions during synthesis.
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