OPSS-Poly(L-Arginine) (OPSS-PArg)
- Full Name: Orthopyridyl Disulfide‑functionalized Poly(L‑Arginine) Hydrochloride
- Appearance: White/off‑white lyophilized powder
- Solubility: Highly soluble in water; soluble in DMSO/MeOH
- Key Features:
- Cationic polyamino acid with guanidinium side chains; strong positive charge in aqueous media
- Terminal OPSS (orthopyridyl disulfide) group for thiol‑disulfide exchange with ‑SH‑containing molecules (proteins, peptides, surfaces)
- Reversible disulfide linkage; cleavable under reducing conditions (e.g., GSH in cells)
- Cell‑penetrating; strong nucleic acid binding; biocompatible
- Main Applications:
- Thiol‑selective bioconjugation (protein/peptide labeling, surface modification)
- Redox‑responsive gene/drug delivery (polyplexes with DNA/RNA)
- Cell culture coating & biosensor assembly
- Layer‑by‑layer (LbL) assembly with anionic polymers
- Storage: −20 °C, desiccated, avoid light & repeated freeze‑thaw
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.