N,N-Bis(PEG2-propargyl)-N-amido-PEG2-maleimide
This product is a multifunctional PEG linker containing a maleimide group, an amide linkage, and two PEG2-propargyl arms. The maleimide selectively reacts with thiols, while the terminal alkynes on the PEG2 chains enable copper-catalyzed or strain-promoted azide-alkyne cycloaddition (CuAAC/SPAAC), allowing orthogonal bioconjugation.
Key Features and Benefits:
-
Maleimide Group: Provides thiol-selective reactivity for cysteine conjugation.
-
Dual Propargyl Groups: Enable efficient multivalent click chemistry with azides.
-
PEG2 Spacers: Improve solubility, flexibility, and reduce steric hindrance.
-
Amide Linkage: Enhances stability in conjugation workflows.
-
High Purity: Reliable performance for protein, peptide, and biomolecule crosslinking.
Applications:
-
Bioconjugation: Dual-mode linker for thiol and azide-based conjugations.
-
Click Chemistry: Multivalent attachment via propargyl groups to azide-bearing molecules.
-
Antibody-Drug Conjugates (ADCs): Enables orthogonal conjugation strategies.
-
Surface Modification: Functionalize nanoparticles, polymers, or hydrogels with thiol and click-reactive handles.
Storage and Handling:
-
Storage: Store at –20 °C, protected from moisture and light.
-
Handling: Use anhydrous solvents (e.g., DMSO, DMF) to maintain maleimide and alkyne reactivity.
This product combines thiol selectivity with dual click chemistry handles, offering an especially versatile platform for orthogonal and multivalent conjugation in advanced bioconjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
