N,N-Bis(PEG2-azide)-N-PEG2-oxyamine
This product is a multifunctional PEG linker containing two azide groups and one oxyamine group, connected via short PEG2 spacers. The azides enable click chemistry with alkynes, while the oxyamine allows chemoselective ligation with aldehydes or ketones, making it an especially effective tool for orthogonal and multivalent bioconjugation.
Key Features and Benefits:
-
Dual Azide Groups: Support multivalent CuAAC or SPAAC click chemistry.
-
Oxyamine Functionality: Enables selective oxime ligation with aldehydes or ketones.
-
PEG2 Spacers: Provide solubility, flexibility, and reduced steric hindrance.
-
Multifunctional Design: Combines click chemistry and oxime ligation for orthogonal strategies.
-
High Purity: Suitable for sensitive bioconjugation and research applications.
Applications:
-
Bioconjugation: Dual-mode conjugation with azide-alkyne and oxime chemistries.
-
Click Chemistry: Efficient linkage to alkyne-bearing biomolecules.
-
Glycoconjugation: Oxyamine reacts with carbonyls in carbohydrates for stable oxime bonds.
-
Surface Modification: Functionalize polymers, nanoparticles, or hydrogels with orthogonal groups.
Storage and Handling:
-
Storage: Store at –20 °C, away from light and moisture.
-
Handling: Use anhydrous solvents (e.g., DMF, DMSO) to maintain azide and oxyamine stability.
This product provides dual click handles and a carbonyl-reactive oxyamine, offering especially versatile options for orthogonal, multivalent, and site-specific conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
