N,N-Bis(PEG2-azide)-N-PEG2-ethanoic NHS Ester
This product is a multifunctional PEG-based linker containing two terminal azides, a PEG2-ethanoic arm, and an active NHS ester. The azides enable bioorthogonal click chemistry with alkynes, while the NHS ester provides rapid and efficient amine coupling, making it ideal for multifunctional and orthogonal conjugation.
Key Features and Benefits:
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Dual Azides: Enable CuAAC and SPAAC click chemistry with alkyne partners.
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NHS Ester Group: Reacts efficiently with primary amines under mild conditions.
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PEG2 Spacers: Enhance solubility, reduce steric hindrance, and increase flexibility.
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High Purity: Ensures reproducibility in advanced bioconjugation workflows.
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Multifunctional Design: Supports orthogonal and stepwise conjugation strategies.
Applications:
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Bioconjugation: Enables dual labeling and orthogonal biomolecule assembly.
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Click Chemistry: Azide–alkyne ligation for traceless, bioorthogonal conjugation.
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Drug Delivery: Useful in multifunctional linker–payload systems.
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Surface Functionalization: Modify nanoparticles, hydrogels, or biosensors with multiple reactivities.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve NHS ester and azide stability.
This product provides a unique combination of dual azide groups and an NHS ester, making it an especially versatile linker for multifunctional and orthogonal bioconjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
