N,N-Bis(PEG2-azide)-N-amido-PEG2-thiol
This product is a multifunctional PEG linker featuring dual azide groups for click chemistry and a thiol group for disulfide or thioether formation. The PEG2 spacers provide solubility and compact flexibility, making it especially effective for orthogonal bioconjugation, probe development, and multifunctional drug delivery strategies.
Key Features and Benefits:
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Dual Azides: Support CuAAC or SPAAC click chemistry with alkynes.
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Thiol Group: Enables disulfide bonding or selective thiol–maleimide conjugation.
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PEG2 Spacers: Enhance solubility and steric accessibility.
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Multifunctional Design: Supports orthogonal and stepwise conjugation.
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High Purity: Provides reproducibility for sensitive applications.
Applications:
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Bioconjugation: Links thiol- and azide-compatible biomolecules.
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Probe Development: Builds multifunctional probes for diagnostics and imaging.
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Drug Delivery: Provides scaffolds with dual click handles and thiol reactivity.
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Synthetic Chemistry: Useful in modular orthogonal linker systems.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid premature thiol oxidation.
This product integrates dual azide groups with thiol functionality in a PEG2 scaffold, specifically offering solubility and orthogonal reactivity for advanced conjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
