N,N-Bis(PEG1-azide)-N-amido-PEG2-thiol
This product is a high-purity PEG linker with two azides for CuAAC or SPAAC click chemistry and a thiol for maleimide, haloacetyl, or disulfide coupling. PEG spacers improve solubility, flexibility, and reduce steric hindrance, making it especially ideal for multifunctional, orthogonal bioconjugation in aqueous and organic systems.
Key Features and Benefits
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Dual Azide Groups: Support CuAAC and SPAAC click reactions for multi-site attachment.
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Thiol Group: Couples with maleimides, haloacetyls, or participates in disulfide formation.
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PEG Spacers: Improve solubility, flexibility, and accessibility of reactive groups.
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Heterobifunctional Design: Enables orthogonal and multifunctional conjugation workflows.
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High Purity: Supplied at >95% purity for reproducibility.
Applications
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Multi-site labeling of biomolecules.
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Crosslinking proteins, peptides, or polymers.
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Orthogonal bioconjugation in diagnostics and therapeutics.
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Nanoparticle and surface functionalization.
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Development of multifunctional drug delivery systems.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to maintain thiol reactivity.
This product offers dual azide click handles and a reactive thiol for orthogonal, multi-site bioconjugation, with PEG spacers specifically for solubility and flexibility in complex functionalization workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
