N,N-Bis(PEG1-azide)-N-amido-PEG2-amine
N,N-Bis(PEG1-azide)-N-amido-PEG2-amine is a high-purity trifunctional PEG linker with two azide groups for bioorthogonal click chemistry (CuAAC or SPAAC) and a terminal primary amine for further conjugation. The PEG1 and PEG2 spacers enhance aqueous solubility, improve flexibility, and reduce steric hindrance, enabling efficient multi-point bioconjugation in both aqueous and organic systems. This design supports the creation of multifunctional, branched conjugates for advanced drug delivery, diagnostics, and materials science.
Key Features and Benefits
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Dual Azide Groups: Allow simultaneous or sequential click chemistry with alkyne-functionalized molecules.
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Primary Amine: Couples readily with carboxylic acids, activated esters, or isocyanates.
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PEG1 + PEG2 Spacers: Improve solubility, flexibility, and functional group accessibility.
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Trifunctional Design: Enables branched or multi-label constructs for complex applications.
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High Purity: Supplied at >95% purity for reproducibility and reliable performance.
Applications
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Multifunctional Bioconjugation: Build branched or multi-labeled biomolecules.
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Protein and Peptide Modification: Attach two alkyne-bearing molecules while coupling to an acid or ester.
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Nanoparticle Functionalization: Introduce multiple reactive handles for surface engineering.
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Drug Delivery Systems: Design multi-point linkers for targeted and controlled payload release.
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Diagnostic Probe Development: Create multifunctional probes for imaging and sensing.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to preserve azide reactivity.
N,N-Bis(PEG1-azide)-N-amido-PEG2-amine offers two azide click handles and an amine coupling site in a soluble, flexible PEG framework, making it an excellent choice for multifunctional bioconjugates, targeted delivery, and diagnostic tools.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
