N,N-Bis(PEG1-azide)-N-4-oxo-butanoic acid
This product is a high-purity trifunctional linker with two terminal azides for copper-catalyzed (CuAAC) or strain-promoted (SPAAC) click chemistry and a 4-oxo-butanoic acid for amide coupling. The short PEG1 spacers specifically enhance solubility and reduce steric hindrance, enabling efficient and orthogonal conjugation in aqueous and organic systems.
Key Features and Benefits
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Dual Azide Groups – Enable simultaneous or sequential CuAAC and SPAAC click reactions
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4-Oxo-butanoic Acid – Reacts with primary amines to form stable amide bonds
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PEG1 Spacers – Improve solubility and flexibility while minimizing steric interference
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Orthogonal Reactivity – Supports multi-step, site-specific modifications
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High Purity – >95% for reproducible results in sensitive applications
Applications
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Multifunctional probe and drug conjugate development
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Protein and peptide dual-labeling
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Crosslinking and bioconjugation in complex systems
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Advanced materials and hydrogel functionalization
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Biosensor and diagnostic assay construction
Storage and Handling
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Store at –20 °C, dry, and protected from light
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Use anhydrous solvents such as DMSO or DMF
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Avoid prolonged exposure to moisture
This product features two azides for click chemistry and a 4-oxo-butanoic acid for amide coupling, with PEG1 spacers for solubility and flexibility, enabling especially versatile multifunctional bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
