NH2-C5-PEG4-N3-L-Lysine-PEG3-N3 is a multifunctional PEG-based linker commonly used in bioconjugation and antibody-drug conjugate (ADC) development. Its structure includes a cleavable PEG spacer, azide groups for click chemistry, and an amino group for additional functionalization, making it versatile for a wide range of applications.
Key Features:
- Cleavable Linker: Allows targeted drug release at the desired site, boosting ADC efficacy.
- Dual Azide Groups: Supports click chemistry reactions such as CuAAC and SPAAC for easy bioconjugation.
- PEG Spacer: Increases solubility, reduces aggregation, and minimizes immunogenicity.
Applications:
- ADC Development: Links antibodies to cytotoxic drugs for targeted cancer therapy.
- Bioconjugation: Attaches biomolecules like peptides or proteins for research or therapeutic uses.
How to Use:
- Storage: Keep at -20°C, away from light and moisture, to maintain stability.
- Solubility: Dissolves well in organic solvents such as DMSO, ensuring compatibility with standard conjugation protocols.
This linker is a powerful tool for drug development and bioconjugation, offering flexibility, stability, and precise targeting capabilities.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
