N-(Propargyl-PEG2)-N-bis(PEG1-alcohol)
This product is a high-purity trifunctional PEG derivative featuring a propargyl group for copper-catalyzed azide–alkyne cycloaddition (CuAAC) and two terminal hydroxyl groups for versatile chemical modification. The PEG2 and PEG1 segments enhance water solubility, reduce steric hindrance, and provide flexibility for orthogonal conjugation strategies.
Key Features and Benefits
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Propargyl Group: Enables efficient CuAAC “click” chemistry with azides under mild conditions.
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Dual Hydroxyl Groups: Serve as handles for esterification, ether formation, or activation to reactive intermediates.
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PEG Architecture: Combines PEG2 and PEG1 units to improve hydrophilicity and accessibility of functional groups.
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Heterofunctional Design: Allows orthogonal, multi-step modification.
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High Purity: Supplied at >95% purity for consistent results.
Applications
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Orthogonal bioconjugation strategies.
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Preparation of multifunctional biomaterials.
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Synthesis of drug delivery systems.
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Surface and nanoparticle functionalization.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents (e.g., DMSO, DMF); minimize moisture exposure.
A trifunctional PEG linker with a propargyl group for click chemistry and dual hydroxyls for versatile modification, offering high solubility and orthogonal reactivity.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
