N-Boc-N-bis(PEG3-NHS ester)
This product is a multifunctional crosslinker featuring a Boc-protected amine core and two PEG3 arms terminated with NHS esters. The NHS groups react efficiently with primary amines to form stable amide bonds, while the Boc group protects the central amine until selective deprotection. The PEG3 chains improve solubility and reduce steric hindrance, making this reagent especially useful for controlled bioconjugation, crosslinking, and drug delivery design.
Key Features and Benefits
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Dual NHS Esters: Couple efficiently with amines for stable amide bond formation.
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Boc-Protected Amine: Provides orthogonal reactivity after selective deprotection.
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PEG3 Spacers: Enhance solubility and flexibility while reducing steric effects.
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Multifunctional Design: Combines protected amine chemistry with dual amine reactivity.
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High Purity: Produced to ≥95% purity for reliable performance.
Applications
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Protein Crosslinking: Links two amine-containing biomolecules with PEG spacing.
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Bioconjugation: Enables sequential modifications with orthogonal protection.
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Drug Delivery: Functions as a modular linker in controlled therapeutic systems.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Deprotect Boc under standard acidic conditions; prepare fresh NHS-ester solutions to avoid hydrolysis.
This product combines orthogonal Boc protection with dual NHS ester reactivity on PEG3 chains, specifically offering versatility for controlled conjugation and crosslinking strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
