N-(Azido-PEG4)-N-bis(PEG4-NHS ester)
This product is a multifunctional PEG linker containing an azide group, two NHS esters, and PEG4 spacers. It enables copper-catalyzed or strain-promoted click reactions with alkynes, along with efficient amine coupling via NHS esters, specifically offering a powerful tri-functional scaffold for bioconjugation.
Key Features and Benefits
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Azide Group: Reacts with alkynes through CuAAC or SPAAC click chemistry.
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Dual NHS Esters: Couple efficiently with primary amines for stable amide bonds.
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PEG4 Spacers: Provide solubility and reduce steric hindrance.
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Multifunctional Design: Combines click chemistry with dual amine reactivity.
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High Purity: Ensures reproducibility in complex conjugation workflows.
Applications
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Bioconjugation: Links alkynes and amine-containing biomolecules in multifunctional assemblies.
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Probe Development: Builds tri-functional probes for diagnostics and imaging.
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Drug Delivery: Provides scaffolds for controlled, multi-point conjugation.
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Material Science: Functionalizes polymers and nanoparticles with orthogonal handles.
Storage and Handling
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Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO to preserve reactivity.
This product integrates azide click chemistry with dual NHS ester coupling in PEG4 scaffolds, specifically providing a versatile tri-functional linker for advanced bioconjugation and material applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
