m-PEG2-Mal is a bifunctional polyethylene glycol (PEG) linker specifically designed for thiol-based conjugation. More importantly, it features a maleimide (Mal) functional group that rapidly and efficiently attaches to thiol-containing molecules. Additionally, the short PEG2 spacer improves solubility, reduces steric hindrance, and enhances biocompatibility. As a result, researchers frequently use this versatile reagent in bioconjugation, targeted drug delivery, and protein modification applications. Furthermore, its ease of use and stability make it an excellent choice for scientific advancements in pharmaceuticals and biotechnology.
Key Features
- Maleimide Functional Group – Quickly and selectively conjugates with thiol-containing biomolecules, ensuring stable linkage formation and reliable results.
- Short PEG2 Spacer – Provides flexibility while reducing steric hindrance, thereby streamlining reaction efficiency and enhancing overall performance.
- Enhanced Solubility – Increases hydrophilicity, making it highly effective in both aqueous and organic environments.
- High Biocompatibility – Reduces immunogenicity and prevents unwanted interactions, ensuring excellent compatibility with biological systems.
- Versatile Applications – Supports drug delivery, protein engineering, and surface modification, thus serving as a valuable tool in biotechnology and pharmaceutical research.
Applications
- Bioconjugation and Labeling – Enables researchers to achieve site-specific conjugation with proteins, peptides, and antibodies, thereby advancing biomedical research and diagnostics.
- Targeted Drug Delivery – Plays a crucial role in modifying drug carriers, which ultimately enhances therapeutic efficacy and stability.
- Protein and Antibody Modification – Helps scientists achieve precise functionalization in protein engineering, leading to improved research outcomes.
- Surface and Nanoparticle Functionalization – Enhances biointerface design for biosensors, nanomedicine, and biomedical coatings, which leads to groundbreaking technological applications.
Conclusion
In summary, m-PEG2-Mal provides a highly efficient and versatile PEG-based linker specifically engineered for thiol-based conjugation. Moreover, with its maleimide functional group, short PEG2 spacer, and excellent solubility, it delivers an optimal solution for bioconjugation, drug delivery, and protein modification. Additionally, its exceptional biocompatibility and stability make it an indispensable component in cutting-edge biomedical and pharmaceutical research. Therefore, researchers seeking reliable and effective conjugation solutions should strongly consider incorporating m-PEG2-Mal into their work.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
