Methyltetrazine-PEG8-PFP ester
This product is a heterobifunctional linker containing a methyltetrazine group for rapid, copper-free IEDDA ligation with TCO and a tetrafluorophenyl (PFP) ester for efficient amine coupling. The PEG8 spacer improves solubility, flexibility, and spacing, making it especially effective in bioorthogonal labeling, ADC development, and drug delivery.
Key Features and Benefits:
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Methyltetrazine Group: Enables ultrafast IEDDA click reactions with TCO.
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PFP Ester: Couples efficiently with amines under mild conditions.
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PEG8 Spacer: Provides solubility, hydrophilicity, and steric accessibility.
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Dual Reactivity: Combines bioorthogonal and amine-targeted chemistries.
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High Purity: Ensures reproducibility in sensitive applications.
Applications:
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Bioorthogonal Labeling: Supports fast copper-free conjugation in vitro and in vivo.
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ADC Development: Provides cleavable and efficient linkers for therapeutic conjugates.
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Probe Development: Builds multifunctional probes for diagnostics and imaging.
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Drug Delivery: Enhances PEGylated systems with bioorthogonal handles.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); prepare fresh solutions before use.
This product combines ultrafast tetrazine ligation with amine-reactive ester chemistry in a PEG8 scaffold, specifically offering solubility, versatility, and high efficiency for bioconjugation and therapeutic development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.