Methyltetrazine-PEG5-Methyltetrazine is a symmetric, homobifunctional linker featuring two tetrazine groups connected by a hydrophilic PEG spacer. This compound is designed for dual bioorthogonal conjugation, enabling efficient labeling and crosslinking of biomolecules.
Key Features
- Dual Methyltetrazine Groups
Facilitates rapid and selective bioorthogonal IEDDA reactions with strained alkenes (e.g., trans-cyclooctene). - PEG5 Spacer
Enhances solubility in aqueous environments and reduces steric hindrance, improving reaction efficiency. - Symmetric Design
Enables dual labeling or crosslinking in a single step.
Applications
- Crosslinking of Biomolecules
Ideal for creating bioconjugates or linking biomolecules with strained alkenes. - Drug Delivery Systems
Useful for designing multifunctional and targeted therapeutics. - Molecular Probes
Facilitates the development of dual-labeled imaging agents. - Material Science
Suitable for functionalizing surfaces, polymers, and nanoparticles.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
