Methyltetrazine-PEG4-SSPy is a cleavable, heterobifunctional linker featuring methyltetrazine for bioorthogonal click chemistry, a disulfide bond for controlled cleavage under reducing conditions, and a pyridyl disulfide (SSPy) group for thiol-specific conjugation. The PEG4 spacer enhances solubility and reduces steric hindrance.
Key Features
- Methyltetrazine Group
Enables rapid, selective bioorthogonal IEDDA reactions with strained alkenes (e.g., trans-cyclooctene). - Pyridyl Disulfide (SSPy) Group
Reacts with free thiols to form stable disulfide linkages. - Cleavable Disulfide Bond
Allows controlled molecule release under reducing conditions. - PEG4 Spacer
Enhances solubility and minimizes steric effects during reactions.
Applications
- Bioconjugation
Ideal for dual functionalization of biomolecules, such as proteins and peptides. - Controlled Drug Release
Facilitates the creation of cleavable drug delivery systems. - Molecular Probes
Enables the development of functional probes for imaging or diagnostics. - Surface Modification
Suitable for functionalizing nanoparticles, hydrogels, and other materials.
Short Description
Methyltetrazine-PEG4-SSPy is a cleavable linker with methyltetrazine for IEDDA reactions, SSPy for thiol conjugation, and a disulfide bond for controlled release. Ideal for bioconjugation and drug delivery applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
