Methyltetrazine-PEG24-t-butyl ester
This high-purity PEG linker features a methyltetrazine for rapid, catalyst-free ligation with TCO and a tert-butyl ester–protected carboxyl for mild deprotection. The long PEG24 spacer ensures exceptional solubility, flexibility, and minimal steric hindrance for especially efficient bioconjugation in aqueous and organic systems.
Key Features and Benefits
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Methyltetrazine Group – Ultra-fast, catalyst-free ligation with TCO for bioorthogonal labeling.
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Tert-butyl Ester Group – Mild, selective deprotection to yield a free carboxylic acid.
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PEG24 Spacer – Exceptional solubility, extended reach, and minimal steric hindrance.
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Orthogonal Reactivity – Ideal for sequential, site-specific conjugations without cross-reactivity.
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High Purity – Supplied at >95% purity for consistent, reproducible performance.
Applications
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Bioorthogonal labeling with TCO-modified biomolecules
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Antibody–drug conjugate (ADC) linker chemistry
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Targeted drug delivery and controlled release systems
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Multifunctional probe and imaging agent development
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid moisture exposure to maintain reactivity
This product enables fast TCO ligation and mild deprotection, with PEG24 specifically providing superior solubility, flexibility, and bioconjugation efficiency.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
