Methyltetrazine-PEG24-NH-Boc
This product is a heterobifunctional linker featuring a methyltetrazine group for ultrafast IEDDA bioorthogonal ligation and a Boc-protected amine for orthogonal synthesis. The PEG24 spacer provides excellent solubility, flexibility, and long spacing, making it especially useful for bioconjugation, ADC development, and probe design.
Key Features and Benefits:
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Methyltetrazine Group: Reacts rapidly with trans-cyclooctenes (TCO) in catalyst-free IEDDA click chemistry.
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Boc-Protected Amine: Acid-labile protection supports orthogonal conjugation.
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PEG24 Spacer: Offers extended solubility, hydrophilicity, and reduced steric hindrance.
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Dual Reactivity: Combines bioorthogonal ligation with protected amine chemistry.
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High Purity: Ensures reproducibility in advanced workflows.
Applications:
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Bioorthogonal Labeling: Enables ultrafast, catalyst-free conjugation with TCO-modified molecules.
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ADC Development: Supports long-chain PEGylation for antibody–drug conjugates.
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Probe Development: Builds multifunctional, cleavable probes for imaging and diagnostics.
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Drug Delivery: Enhances solubility and circulation of conjugates in therapeutic applications.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid premature Boc deprotection.
This product combines bioorthogonal tetrazine chemistry with a Boc-protected amine in a PEG24 scaffold, offering long-chain spacing specifically for advanced conjugation and therapeutic applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
