Methyltetrazine-PEG2-SS-PEG2-Methyltetrazine (bis Methyltetrazine-PEG2-disulfide) is a symmetric, cleavable homobifunctional linker featuring two methyltetrazine groups connected by PEG2 spacers and a central disulfide (SS) bond. This compound is designed for reversible bioconjugation and controlled molecule release under reducing conditions.
Key Features
- Cleavable Disulfide Bond
Allows controlled cleavage under reducing environments, enabling the release of conjugated molecules. - Dual Methyltetrazine Groups
Supports bioorthogonal click chemistry via rapid and selective IEDDA reactions with strained alkenes (e.g., trans-cyclooctene). - Hydrophilic PEG2 Spacers
Improves aqueous solubility and reduces steric hindrance, facilitating efficient reactions.
Applications
- Reversible Bioconjugation
Ideal for creating linkages that can be cleaved under mild reducing conditions, such as in intracellular environments. - Drug Delivery
Enables the development of cleavable drug delivery systems for targeted therapeutic release. - Protein and Peptide Crosslinking
Facilitates dual functionalization of biomolecules in advanced studies. - Molecular Imaging and Diagnostics
Suitable for designing probes or diagnostic agents requiring temporary conjugation.
Advantages
This linker combines the specificity of methyltetrazine-based click chemistry with the controlled cleavability of disulfide bonds, making it an excellent tool for applications that demand both stability and reversibility.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
