Methyltetrazine-PEG12-t-butyl ester
Methyltetrazine-PEG12-t-butyl ester is a high-purity heterobifunctional linker with a methyltetrazine for rapid, catalyst-free inverse electron-demand Diels–Alder (IEDDA) click chemistry with trans-cyclooctene (TCO) and a tert-butyl-protected carboxylic acid for controlled deprotection. The PEG12 spacer enhances solubility, flexibility, and reduces steric hindrance, specifically enabling efficient conjugations in aqueous and organic systems. This reagent is especially ideal for orthogonal bioconjugation, targeted delivery, and multi-step synthetic workflows.
Key Features and Benefits
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Methyltetrazine Group: Enables ultra-fast, catalyst-free IEDDA reaction with TCOs.
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t-Butyl Ester Protection: Allows mild acidic deprotection to yield a reactive carboxylic acid.
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PEG12 Spacer: Provides excellent solubility and flexibility, minimizing steric effects.
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Heterobifunctional Design: Supports orthogonal, site-specific modifications.
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High Purity: Supplied at >95% purity for reproducibility.
Applications
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Orthogonal click chemistry for bioconjugation.
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Multi-step labeling strategies.
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Targeted drug delivery systems.
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Nanoparticle and surface functionalization.
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Biomaterial engineering.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to preserve reactivity and t-butyl protection.
This product enables fast IEDDA click chemistry with TCOs and offers controlled carboxylic acid generation after deprotection, with a PEG12 spacer specifically for solubility and flexibility in advanced bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
