Methyltetrazine-PEG12-DBCO CAS:2183440-28-8 is a versatile bioconjugation reagent composed of a methyltetrazine moiety, a hydrophilic polyethylene glycol (PEG) linker, and a DBCO functional group. The methyltetrazine reacts via bioorthogonal inverse electron-demand Diels-Alder chemistry, while the PEG12 spacer enhances solubility and reduces steric hindrance. The DBCO group facilitates copper-free click chemistry, ensuring biocompatibility and rapid conjugation with azide-tagged biomolecules.
In pharmaceutical research and development, Methyltetrazine-PEG12-DBCO is employed for site-specific bioconjugation and bioorthogonal chemistry. It enables the creation of targeted drug delivery systems, antibody-drug conjugates, and imaging probes with minimal disruption to native biological functions. Its copper-free click chemistry and rapid reaction kinetics streamline the conjugation process, while the hydrophilic PEG12 linker preserves the biological activity and stability of the conjugated molecules, advancing drug discovery and diagnostics.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
