Methylcyclopropene-PEG3-amine CAS:2749286-00-6 is a small molecule linker that is commonly used in the field of bioconjugation and drug delivery. It contains several functional groups, including an amine group, a cyclopropene group, and a PEG (polyethylene glycol) chain.
The amine group in Methylcyclopropene-PEG3-amine can react with carboxylic acids, isocyanates, and other reactive groups, forming stable covalent linkages with other molecules. The cyclopropene group, on the other hand, can undergo a copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction with azide-containing molecules, such as fluorescent dyes or targeting ligands, allowing for site-specific labeling or functionalization of the linker.
The PEG chain in Methylcyclopropene-PEG3-amine provides several benefits for bioconjugation and drug delivery applications. PEG is hydrophilic and biocompatible, which can improve the solubility, stability, and biocompatibility of drugs or nanoparticles. Additionally, the flexible and elongated nature of the PEG chain can prevent protein adsorption, reduce immunogenicity, and prolong the circulation time of drugs in the body.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.