Mal-amido-PEG3-NHS ester
Mal-amido-PEG3-NHS ester is a high-purity heterobifunctional PEG linker featuring a maleimide group for thiol-specific conjugation and an NHS ester for efficient amine coupling. The PEG3 spacer improves aqueous solubility, increases flexibility, and reduces steric hindrance, enabling high-yield bioconjugation in both aqueous and organic systems. This orthogonal reactivity makes it ideal for stepwise conjugation strategies in drug delivery, diagnostics, and biomaterials.
Key Features and Benefits
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Maleimide Group: Selectively reacts with thiols to form stable thioether bonds under mild conditions.
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NHS Ester: Rapidly couples to primary amines, forming stable amide bonds.
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PEG3 Spacer: Enhances solubility, flexibility, and accessibility of reactive sites.
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Heterobifunctional Design: Supports orthogonal, stepwise conjugation workflows.
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High Purity: Supplied at >95% purity for reproducible, reliable performance.
Applications
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Protein and Peptide Modification: Attach thiol-containing biomolecules while coupling to amines.
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Antibody–Drug Conjugates (ADCs): Link drugs or payloads via orthogonal thiol and amine chemistries.
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Nanoparticle Functionalization: Add bioorthogonal handles for targeted delivery systems.
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Surface Modification: Functionalize biosensors, polymers, or hydrogels.
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Diagnostic Probes: Build multifunctional imaging and sensing agents.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to preserve NHS ester and maleimide reactivity.
Mal-amido-PEG3-NHS ester combines thiol-reactive and amine-reactive chemistries in a hydrophilic PEG3 framework, enabling especially efficient, orthogonal bioconjugation for multifunctional linkers, drug delivery, and diagnostic applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
