Mal-amido-PEG1 NHS Ester (CAS: 1260092-50-9)
Mal-amido-PEG1 NHS Ester serves as a versatile bifunctional linker for bioconjugation and drug development. Its maleimide group reacts selectively with thiol-containing molecules, forming stable thioether bonds, while its NHS ester efficiently couples with primary amines, creating strong amide bonds. Additionally, its PEG1 spacer improves solubility and flexibility, ensuring more effective and less sterically hindered conjugation processes.
Key Features:
- Reactive Groups:
- Maleimide: Binds specifically to thiol groups, enabling targeted conjugation with cysteine residues in proteins.
- NHS Ester: Forms stable amide bonds with primary amines on lysine residues or N-terminal amines.
- PEG1 Spacer:
- Increases water solubility, allowing compatibility with aqueous environments.
- Provides molecular flexibility, minimizing steric interference during conjugation.
Applications:
- Bioconjugation:
- Links peptides, proteins, and antibodies by reacting with thiol and amine groups.
- Drug Development:
- Functions as a key linker in creating antibody-drug conjugates (ADCs) and other targeted therapeutics, improving drug efficacy and stability.
Handling and Storage:
- Molecular Formula: C₁₆H₁₉N₃O₈
- Molecular Weight: 381.34 g/mol
- Storage Recommendations:
- Store at -20°C in a cool, dry place, away from light and moisture to maintain its chemical stability.
Overall, Mal-amido-PEG1 NHS Ester supports advanced molecular research by enabling precise and stable bioconjugation. Its dual reactivity, combined with a solubility-enhancing PEG1 spacer, makes it an essential tool for chemical biology, pharmaceutical development, and drug delivery research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
