Mal-PEG6-t-butyl ester
Mal-PEG6-t-butyl ester is a high-purity heterobifunctional PEG linker with a maleimide group for thiol-specific conjugation and a t-butyl ester-protected carboxylic acid for controlled activation. The PEG6 spacer enhances solubility, flexibility, and reduces steric hindrance, enabling efficient bioconjugation in both aqueous and organic systems. The t-butyl ester protection allows the carboxylic acid to remain inert until selective deprotection under mild acidic conditions.
Key Features and Benefits
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Maleimide Group: Selectively reacts with thiols to form stable thioether bonds.
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t-Butyl Ester-Protected Carboxylic Acid: Stable under neutral and basic conditions; easily deprotected to a reactive acid.
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PEG6 Spacer: Improves solubility, flexibility, and accessibility of reactive groups.
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Heterobifunctional Design: Supports orthogonal, stepwise conjugation strategies.
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High Purity: Supplied at >95% purity for reliable and reproducible performance.
Applications
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Stepwise Bioconjugation: Conjugate thiols first, then deprotect the acid for secondary coupling.
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Protein and Peptide Modification: Attach thiol-containing biomolecules with controlled acid activation.
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Nanoparticle and Surface Functionalization: Introduce thiol-reactive handles and a latent acid group.
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Drug Delivery Systems: Build multifunctional linkers for controlled payload release.
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Diagnostic and Imaging Probes: Prepare probes with sequential modification capability.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture to maintain reactivity.
Mal-PEG6-t-butyl ester combines thiol reactivity with a protected acid in a hydrophilic PEG6 framework, specifically offering flexibility for orthogonal bioconjugation in therapeutics, diagnostics, and materials science.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
