Mal-PEG4-tris-alkyne
Mal-PEG4-tris-alkyne is a versatile PEG linker designed for advanced bioconjugation and chemical biology. It features a maleimide group for thiol-specific conjugation and three terminal alkyne groups for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions. The PEG4 spacer enhances water solubility, flexibility, and reduces steric hindrance, making it suitable for various biological and chemical applications.
Key Features
- Dual Functional Groups:
- Maleimide: Forms stable bonds with thiol groups (-SH).
- Tris-Alkyne: Provides three reactive sites for CuAAC (“click chemistry”) with azides.
- PEG Linker:
- PEG4 improves water solubility and flexibility.
- Reduces steric hindrance for efficient conjugation.
- Biocompatibility:
- Non-toxic and ideal for in vitro and in vivo applications.
Applications
- Bioconjugation:
Links peptides, proteins, or other biomolecules through thiol and alkyne chemistry, enabling multi-functional conjugation. - Drug Delivery:
Acts as a linker in drug delivery systems, improving solubility and stability. - Nanotechnology:
Functionalizes nanoparticles, biosensors, and medical devices for targeted labeling or modification. - Chemical Biology:
Supports multi-point conjugation and complex molecule synthesis using CuAAC.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
