Mal-PEG3-t-butyl ester
This product is a bifunctional PEG linker containing a maleimide group, a PEG3 spacer, and a tert-butyl ester. It specifically enables thiol-specific conjugation and provides a protected acid group for controlled deprotection in synthesis and bioconjugation.
Key Features and Benefits
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Maleimide Group: Couples selectively with thiols to form stable thioether bonds.
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t-Butyl Ester: Protects the carboxyl group for controlled release.
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PEG3 Spacer: Improves solubility with a compact chain length.
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Dual Reactivity: Combines thiol conjugation with protected acid functionality.
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High Purity: Ensures reproducibility in advanced bioconjugation workflows.
Applications
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Bioconjugation: Links thiol-containing biomolecules with PEG scaffolds.
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Probe Development: Builds multifunctional probes with orthogonal handles.
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Drug Delivery: Provides PEG scaffolds with thiol reactivity and protected carboxyl groups.
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Organic Synthesis: Serves as an intermediate for modular linker design.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid premature hydrolysis.
This product integrates maleimide thiol reactivity with a protected carboxyl group in a PEG3 scaffold, specifically offering flexibility for staged conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
