Mal-PEG3-CH2COOH
Mal-PEG3-CH2COOH is a high-purity heterobifunctional PEG linker with a maleimide group for thiol-specific conjugation and a terminal carboxylic acid for amide bond formation. The PEG3 spacer enhances solubility, flexibility, and reduces steric hindrance, enabling efficient bioconjugation in both aqueous and organic systems. This design is ideal for orthogonal conjugation strategies where thiol reactivity and carboxyl coupling are required.
Key Features and Benefits
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Maleimide Group: Selectively reacts with thiols to form stable thioether bonds.
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Carboxylic Acid: Ready for activation via carbodiimide or active ester chemistry.
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PEG3 Spacer: Improves solubility, flexibility, and accessibility of reactive groups.
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Heterobifunctional Design: Supports orthogonal and sequential modification strategies.
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High Purity: Supplied at >95% purity for consistent and reproducible results.
Applications
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Stepwise Bioconjugation: Attach thiol-containing biomolecules before carboxyl activation.
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Protein and Peptide Modification: Couple thiol-reactive handles with carboxylic acid chemistry.
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Nanoparticle and Surface Functionalization: Add thiol and acid functionalities to surfaces.
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Drug Delivery Systems: Create multifunctional linkers for targeted therapeutic payloads.
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Diagnostic and Imaging Probes: Prepare dual-functional probes for orthogonal conjugation.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture to maintain reactivity.
Mal-PEG3-CH2COOH combines thiol reactivity and a terminal carboxylic acid in a hydrophilic PEG3 framework, offering versatility for orthogonal bioconjugation in therapeutics, diagnostics, and materials science.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
