Mal-PEG2-t-Butyl ester
This product is a heterobifunctional linker containing a maleimide group, a PEG2 spacer, and a protected t-butyl ester. The maleimide reacts selectively with thiols to form stable thioether bonds, while the t-butyl ester can be deprotected under mild acidic conditions to yield a free carboxylic acid for further conjugation. The PEG2 spacer specifically enhances solubility and flexibility, making this a versatile intermediate for bioconjugation and drug delivery research.
Key Features and Benefits
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Maleimide Group: Couples selectively with thiols to form stable linkages.
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t-Butyl Ester: Protects the acid terminus until deprotection is desired.
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PEG2 Spacer: Improves solubility, flexibility, and biomolecule accessibility.
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Stepwise Conjugation: Enables controlled sequential modifications.
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High Purity: Manufactured to ≥95% purity for reliable results.
Applications
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Bioconjugation: Links thiol- and amine-containing biomolecules.
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Drug Delivery: Serves as a protected intermediate in PEGylated therapeutics.
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Probe Development: Builds multifunctional probes for diagnostics and imaging.
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Organic Synthesis: Useful for stepwise linker strategies in custom conjugates.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Deprotect t-butyl ester under mild acidic conditions; prepare fresh solutions as needed.
This product combines thiol-reactive maleimide chemistry with a protected acid handle in a compact PEG2 design, specifically offering flexibility for controlled bioconjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
