Mal-PEG2-CH2COOH

Mal-PEG2-CH2COOH is a high-purity, bifunctional polyethylene glycol (PEG) derivative featuring a maleimide group and a carboxylic acid group. This molecule serves as a versatile linker for bioconjugation, enabling precise and stable attachment of biomolecules. Moreover, the PEG2 spacer enhances solubility and flexibility, making it an ideal tool in pharmaceutical and biotechnology applications.

Key Features

• Bifunctional Reactivity – The maleimide group reacts selectively with thiols, while the carboxyl group enables coupling with amines, thereby expanding its utility.
• Improved Water Solubility – The PEG2 spacer enhances solubility and reduces aggregation of conjugated molecules, ensuring better performance.
• Defined Spacer Length – Provides an optimal linker length, which is crucial for maintaining biological activity and stability.
• High Purity and Stability – Manufactured under stringent quality control, thus guaranteeing consistent performance.
• Versatile Conjugation – Ideal for modifying proteins, peptides, and small molecules, thereby supporting research and therapeutic applications.

Applications

• Antibody-Drug Conjugates (ADCs) – Facilitates targeted drug delivery by linking cytotoxic agents to antibodies, thereby improving therapeutic efficacy.
• Protein and Peptide Modification – Enables the attachment of biomolecules, which enhances stability and function.
• Drug Delivery Systems – Improves pharmacokinetics by increasing solubility and reducing immunogenicity, thereby optimizing drug performance.
• Surface and Nanoparticle Functionalization – Used in modifying nanoparticles, surfaces, and hydrogels, making it valuable for biomedical research.

Conclusion

In summary, Mal-PEG2-CH2COOH is an essential reagent for bioconjugation, offering reliable and efficient linkage capabilities. Its bifunctional reactivity, improved solubility, and stability make it a valuable tool for pharmaceutical and biotech industries. Whether used in drug development, antibody conjugation, or surface modification, this PEG-based linker ensures optimal performance and consistency for advanced research and therapeutic applications.