Mal-PEG2-bis-PEG3-BCN
Mal-PEG2-bis-PEG3-BCN is a bi-functional PEG linker designed for advanced bioconjugation and chemical biology. It features a maleimide group for thiol-specific conjugation and a BCN (bicyclononyne) group for copper-free bioorthogonal ligation with azides via strain-promoted azide-alkyne cycloaddition (SPAAC). Its PEG2 and bis-PEG3 linkers enhance solubility, flexibility, and reduce steric hindrance, making it ideal for diverse biological and chemical applications.
Key Features
- Dual Functional Groups:
- Maleimide: Reacts with thiol groups (-SH) to form stable thioether bonds.
- BCN: Enables fast, selective copper-free bioorthogonal reactions with azides.
- PEG Linkers:
- PEG2 and bis-PEG3 enhance solubility and reduce steric hindrance.
- Improve flexibility for efficient conjugation.
- Biocompatibility:
- Non-toxic and suitable for in vivo and in vitro use.
Applications
- Bioconjugation: Links peptides, proteins, and nucleic acids through thiol and azide chemistry.
- Drug Delivery: Serves as a linker to enhance solubility and targeting of drug conjugates.
- Nanotechnology: Functionalizes nanoparticles, biosensors, and surfaces for bioorthogonal labeling.
- Chemical Biology: Enables copper-free crosslinking and labeling in live-cell and in vivo systems.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.