Mal-PEG1-t-butyl ester
This product is a bifunctional PEG linker containing a maleimide group, a short PEG1 spacer, and a tert-butyl ester. It specifically enables thiol conjugation through the maleimide and serves as a protected precursor for carboxyl functionality.
Key Features and Benefits
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Maleimide Group: Couples selectively with thiols to form stable thioether bonds.
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t-Butyl Ester: Provides a protected carboxyl group for controlled deprotection.
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PEG1 Spacer: Offers compact solubility and flexibility.
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Dual Functionality: Combines thiol reactivity with protected acid chemistry.
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High Purity: Ensures reproducibility in sensitive conjugation workflows.
Applications
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Bioconjugation: Links thiol-containing proteins, peptides, or small molecules.
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Probe Development: Builds dual-reactive probes with orthogonal handles.
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Drug Delivery: Serves as a protected intermediate for PEGylated scaffolds.
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Organic Synthesis: Provides a versatile building block for custom linkers.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid premature hydrolysis.
This product integrates thiol-reactive maleimide chemistry with a protected carboxyl group in a PEG1 scaffold, specifically offering a compact and versatile linker.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
