Mal-PEG-NHS, MW 20K is a functionalized molecule that is widely used in the field of pharmaceutical research and development. This molecule is composed of three main components: a maleimide group (MAL), a polyethylene glycol (PEG) chain, and a N-hydroxysuccinimide (NHS) ester.
The maleimide group is a thiol-reactive functional group that can selectively and covalently bind to cysteine residues on proteins or peptides. The PEG chain provides water solubility and improves the stability and pharmacokinetics of the conjugated molecules. The NHS ester, on the other hand, is a commonly used linker molecule that reacts with primary amines on proteins, peptides, or small molecules to form stable amide bonds.
The use of Mal-PEG-NHS, MW 20K in pharmaceutical research and development is extensive. It is often utilized for the site-specific conjugation of biomolecules to create targeted drug delivery systems, imaging agents, and diagnostic tools. This functionalized molecule has the ability to improve the pharmacokinetic properties of therapeutic molecules, reduce immunogenicity, and enhance the efficacy of certain drugs.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.