Mal-PEG-Mal, MW 5K

Mal-PEG-Mal, MW 5K

Mal-PEG-Mal, MW 5K is a high-purity homobifunctional PEG linker with maleimide groups at both ends for thiol-specific conjugation. The PEG backbone (5,000 Da) provides excellent water solubility, flexibility, and extended spacing, enabling efficient crosslinking of thiol-containing biomolecules, proteins, or nanoparticles in both aqueous and organic systems. This design is especially ideal for preparing stable, site-specific conjugates in drug delivery, diagnostics, and biomaterials.

Key Features and Benefits

• Dual Maleimide Groups: Enables efficient, selective thiol–maleimide coupling at both ends.

• PEG Backbone (5 kDa): Provides long, flexible, hydrophilic spacing to improve solubility and reduce steric hindrance.

• Homobifunctional Design: Ideal for crosslinking two thiol-containing molecules.

• High Purity: Supplied at >95% purity for reproducibility and reliable performance.

Applications

• Crosslinking cysteine-containing proteins and peptides.

• Nanoparticle and surface modification.

• Development of stable antibody–drug conjugates (ADCs).

• Hydrogel and biomaterial preparation.

• Diagnostic probe assembly.

Storage and Handling

• Storage: Store at –20 °C, dry, and protected from light.

• Handling: Use anhydrous solvents; avoid prolonged exposure to moisture to preserve maleimide reactivity.

This product combines dual maleimide groups with a hydrophilic PEG spacer for efficient thiol crosslinking, offering especially excellent solubility and stability for multifunctional bioconjugates.