Mal-amido-PEG8 NHS ester
Mal-amido-PEG8 NHS ester is a high-purity heterobifunctional PEG linker featuring a maleimide group for thiol-specific conjugation and an NHS ester for efficient coupling to primary amines. The PEG8 spacer improves solubility, flexibility, and spatial separation between conjugated molecules, specifically enabling high-yield and low-nonspecific bioconjugation.
Key Features and Benefits
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Maleimide Group: Reacts selectively with thiols via Michael addition under mild conditions.
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NHS Ester Group: Efficiently couples to amines in aqueous or organic media.
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PEG8 Spacer: Enhances water solubility, reduces steric hindrance, and improves biocompatibility.
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Heterobifunctional Design: Allows orthogonal, sequential conjugation of two distinct functional groups.
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High Purity: Supplied at >95% purity for reproducibility in sensitive applications.
Applications
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Protein–protein or protein–peptide conjugation.
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Antibody–drug conjugate (ADC) synthesis.
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Nanoparticle and surface functionalization.
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Crosslinking for biomaterials and hydrogel preparation.
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Targeted drug delivery systems.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture to maintain NHS ester activity.
A versatile heterobifunctional PEG linker that enables site-specific thiol and amine conjugation with improved solubility and reduced steric hindrance specifically for high-efficiency bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
