Mal-Amido-PEG5-NHS Ester (CAS: 1315355-92-0)
Mal-Amido-PEG5-NHS Ester is a highly versatile crosslinker that significantly simplifies bioconjugation, drug delivery, and material science applications. It combines a maleimide group for thiol reactivity, an NHS ester for amine coupling, and a 5-unit PEG spacer. This unique design ensures excellent solubility, flexibility, and efficiency in various applications.
Key Features
- Functional Groups:
- Maleimide: Reacts specifically with thiol groups to form stable linkages.
- NHS Ester: Couples efficiently with primary amines, creating robust amide bonds.
- PEG Spacer: A 5-unit chain adds flexibility, improves solubility, and minimizes steric hindrance.
- Molecular Weight: Approximately 430–460 g/mol, depending on synthesis.
Applications
1. Bioconjugation
Mal-Amido-PEG5-NHS Ester streamlines biomolecule conjugation. The maleimide group selectively reacts with thiol-containing molecules, while the NHS ester easily couples with primary amines. This dual functionality makes it perfect for attaching proteins, peptides, or antibodies in precise configurations.
2. Drug Delivery
The PEG5 spacer plays a crucial role in enhancing solubility and reducing immunogenicity. It stabilizes therapeutic molecules, enabling their effective delivery and controlled targeting in advanced drug delivery systems.
3. Surface and Material Functionalization
This compound works exceptionally well for modifying surfaces and nanoparticles. The PEG spacer reduces non-specific binding, while its dual reactivity allows you to create flexible and biocompatible coatings, which are essential in biosensors and advanced materials.
Handling and Storage
- Store Mal-Amido-PEG5-NHS Ester at −20°C in a dry, inert environment to maintain its reactivity.
- Protect it from light and moisture to preserve the integrity of the maleimide and NHS ester groups.
- Use it promptly after opening for consistent performance and results.
Overall, this product offers a powerful and efficient solution for bioconjugation, drug delivery, and surface functionalization. Its thiol-reactive maleimide, amine-reactive NHS ester, and flexible PEG5 spacer especially combine to deliver precision, solubility, and reliability across diverse biomedical and material science applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
