Mal-Amido-PEG4-t-butyl ester
This product is a heterobifunctional PEG linker containing a maleimide group, a PEG4 spacer, and a tert-butyl ester. It specifically enables thiol-selective conjugation and provides a protected carboxyl group for controlled deprotection in synthesis and bioconjugation.
Key Features and Benefits
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Maleimide Group: Couples selectively with thiols to form stable thioether bonds.
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t-Butyl Ester: Protects the carboxyl group for controlled release when needed.
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PEG4 Spacer: Enhances solubility and provides flexible spacing.
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Dual Reactivity: Combines thiol chemistry with orthogonal acid protection.
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High Purity: Ensures reproducibility in advanced conjugation workflows.
Applications
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Bioconjugation: Links thiol-containing biomolecules with PEG scaffolds.
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Probe Development: Builds multifunctional probes with thiol and acid handles.
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Drug Delivery: Provides scaffolds with protected carboxyl and thiol-reactive groups.
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Organic Synthesis: Serves as a versatile intermediate in modular linker design.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid premature hydrolysis.
This product integrates maleimide reactivity with a protected carboxyl group in a PEG4 scaffold, specifically offering flexibility for staged conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
