Mal-amide-PEG3-oxyamineBoc
Mal-amide-PEG3-oxyamineBoc is a high-purity heterobifunctional PEG linker with a maleimide group for thiol-specific conjugation and a Boc-protected oxyamine for orthogonal oxime ligation. The PEG3 spacer enhances solubility, improves flexibility, and reduces steric hindrance, enabling efficient bioconjugation in both aqueous and organic systems. The acid-labile Boc group specifically allows controlled deprotection for stepwise functionalization, making it ideal for precision linker design in drug delivery, diagnostics, and advanced materials.
Key Features and Benefits
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Maleimide Group: Reacts selectively with thiols to form stable thioether bonds under mild conditions.
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Boc-Protected Oxyamine: Allows orthogonal oxime ligation after acid deprotection.
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PEG3 Spacer: Enhances solubility, flexibility, and accessibility of reactive groups.
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Heterobifunctional Design: Enables dual-step, orthogonal conjugation strategies.
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High Purity: Supplied at >95% purity for consistent, reproducible performance.
Applications
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Stepwise Bioconjugation: Sequential thiol coupling and oxime ligation.
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Protein and Peptide Modification: Introduce orthogonal functional groups for site-specific labeling.
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Nanoparticle Functionalization: Add bioorthogonal handles for targeted delivery.
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Drug Delivery Systems: Build linkers for stable circulation and triggered payload release.
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Diagnostic Probe Development: Create multifunctional probes for imaging and biosensing.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to preserve maleimide reactivity.
Mal-amide-PEG3-oxyamineBoc offers thiol-reactive maleimide chemistry and orthogonal oxyamine ligation in a compact, hydrophilic PEG3 framework, making it especially versatile for multifunctional bioconjugates and targeted delivery systems.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
