Mal-amide-PEG3-oxyamine
Mal-amide-PEG3-oxyamine is a high-purity heterobifunctional PEG linker with a maleimide group for thiol-specific conjugation and an oxyamine group for chemoselective coupling with carbonyls (aldehydes or ketones). The PEG3 spacer enhances solubility, flexibility, and reduces steric hindrance, enabling efficient bioconjugation in both aqueous and organic systems. This design especially supports orthogonal, stepwise assembly of multifunctional biomolecules, drug conjugates, and advanced materials.
Key Features and Benefits
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Maleimide Group: Selectively reacts with thiols to form stable thioether bonds.
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Oxyamine Group: Couples with aldehydes or ketones via oxime bond formation under mild conditions.
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PEG3 Spacer: Improves water solubility, molecular flexibility, and accessibility of reactive groups.
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Heterobifunctional Design: Allows orthogonal conjugation strategies for complex constructs.
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High Purity: Supplied at >95% purity for reliable and reproducible performance.
Applications
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Stepwise Bioconjugation: Sequentially attach thiol-containing and carbonyl-containing biomolecules.
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Protein and Peptide Modification: Introduce aldehyde-reactive handles alongside thiol labeling.
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Nanoparticle Functionalization: Enable dual functionalization for targeted delivery and sensing.
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Drug Delivery Systems: Build linkers for stable attachment and controlled release.
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Diagnostic Probes: Develop multifunctional imaging and biosensing tools.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to preserve reactivity.
Mal-amide-PEG3-oxyamine combines thiol-specific and aldehyde/ketone-reactive functionalities in a PEG3 spacer, enabling orthogonal, high-yield bioconjugation specifically for advanced therapeutics, diagnostics, and biomaterials.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
