Mal-amide-PEG2-oxyamineBoc
Mal-amide-PEG2-oxyamineBoc is a high-purity heterobifunctional PEG linker with a maleimide group for thiol-specific conjugation and a Boc-protected oxyamine for controlled carbonyl coupling. The PEG2 spacer improves solubility, flexibility, and reduces steric hindrance, enabling efficient bioconjugation in both aqueous and organic systems. The Boc group keeps the oxyamine inert until mild acidic deprotection, allowing orthogonal, stepwise conjugation strategies.
Key Features and Benefits
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Maleimide Group: Selectively reacts with thiols to form stable thioether bonds.
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Boc-Protected Oxyamine: Stable under neutral and basic conditions; deprotected to form an oxyamine for aldehyde/ketone coupling via oxime bonds.
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PEG2 Spacer: Enhances solubility, flexibility, and accessibility of reactive groups.
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Heterobifunctional Design: Supports orthogonal and sequential modification strategies.
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High Purity: Supplied at >95% purity for reproducible and consistent results.
Applications
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Stepwise Bioconjugation: Conjugate thiols first, then deprotect the oxyamine for carbonyl coupling.
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Protein and Peptide Modification: Attach oxyamine handles to thiol-bearing biomolecules.
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Nanoparticle and Surface Functionalization: Equip surfaces with thiol-reactive and carbonyl-reactive groups.
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Drug Delivery Systems: Build multifunctional linkers for targeted and controlled payload attachment.
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Diagnostic and Imaging Probes: Create dual-functional probes with orthogonal chemistries.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture to maintain reactivity.
Mal-amide-PEG2-oxyamineBoc combines thiol reactivity with a protected oxyamine in a compact PEG2 framework, specifically enabling orthogonal bioconjugation in therapeutics, diagnostics, and materials science.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
