Mal-amide-PEG2-oxyamine
This product is a heterobifunctional PEG linker featuring a maleimide group for selective thiol conjugation and a terminal oxyamine for oxime ligation with carbonyls. The PEG2 spacer provides solubility and compact spacing, making it especially effective for multifunctional bioconjugation, probe development, and drug delivery.
Key Features and Benefits:
-
Maleimide Group: Reacts selectively with thiols to form stable thioether bonds.
-
Oxyamine Group: Enables chemoselective oxime ligation with aldehydes/ketones.
-
PEG2 Spacer: Improves solubility and minimizes steric hindrance.
-
Dual Reactivity: Combines thiol and carbonyl-targeted conjugation.
-
High Purity: Ensures reproducibility in advanced applications.
Applications:
-
Bioconjugation: Couples thiols and carbonyl groups in orthogonal strategies.
-
Probe Development: Builds multifunctional imaging and diagnostic tools.
-
Drug Delivery: Provides dual-reactive PEGylated scaffolds.
-
Synthetic Chemistry: Useful intermediate for advanced conjugate design.
Storage and Handling:
-
Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
-
Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid hydrolysis of maleimide and oxyamine groups.
This product combines thiol reactivity with oxyamine ligation in a PEG2 scaffold, specifically offering versatility for orthogonal conjugation and multifunctional probe design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
