m-PEG9-2-Methylacrylate CAS:35236-69-2 is a bifunctional reagent featuring a methoxy polyethylene glycol (mPEG) chain with nine ethylene glycol units and a 2-methylacrylate moiety. The mPEG imparts solubility and biocompatibility to the resulting conjugate, while the 2-methylacrylate group allows for efficient covalent bond formation with biomolecules.
The 2-methylacrylate moiety reacts with nucleophilic groups on biomolecules, such as amines or thiols, in free-radical polymerization or Michael addition reactions, facilitating the attachment of mPEG chains. The PEGylation process improves pharmacokinetic properties, reduces immunogenicity, and increases circulation time in biological systems.
m-PEG9-2-Methylacrylate is widely used in pharmaceutical research and development, including PEGylation of proteins, peptides, and small molecules for drug delivery applications. The compact size of this reagent allows for minimal steric hindrance, enhancing the bioactivity of the conjugate. Its versatility makes it a valuable addition to any biological reagent portfolio.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
